Dorien receives Young Investigator Grant from KWF!

Cognitive disorders are a side effect of chemotherapy that can persist long after the treatment is completed and include problems with working memory and concentration. There is no successful treatment strategy for chemotherapy-related cognitive disorders (CRCI) because clinical and preclinical studies are far apart, creating translational problems in the development of treatments. In the brains of CRCI patients, the harmful effects of chemotherapy are not localized in a specific brain area but rather the ‘connectivity’ or connection between brain areas is affected. This research uses a rat model for CRCI. Using this model, the cellular and molecular changes underlying CRCI are investigated, and different interventions to remedy CRCI are examined. The project title is: Combining clinical and preclinical methods to successfully treat chemotherapy-related cognitive impairments successfully. Stay tuned for this exciting project to start!